• Cyclosporin A, EvoPure packaged and labeled.

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SKU: C042

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Description

Cyclosporin A (CsA) is a neutral, cyclic oligopeptide immunosuppressant compound routinely given to patients after receiving an organ transplant to prevent transplant rejection. Cyclosporin A (CsA) shows the most potent immunosuppressant activity of the cyclosporins and is highly metabolized by humans and animals after ingestion. The resulting metabolites (cyclosporin B, C, D, E, H, L, and others) have been found to have less potent immunosuppressant activity and are associated with higher nephrotoxicity when compared to cyclosporin A (CsA). Cyclosporin A (CsA) has been successful for liver, kidney, bone marrow, and pancreas transplant recipients as well as pateints with autoimmune disorders.

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    CAS Number

    59865-13-3

    Molecular Formula

    C62H111N11O12

    Molecular Weight

    1202.6 g/mol

    Mechanism of Action

    Cyclosporin A (CsA) immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, cyclosporin A (CsA) associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A (CsA) : cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and nitric oxide synthesis by TNFα and interleukin 1α.

    Storage Conditions

    -20°C

    Tariff Code

    2933.79.8500

Applications

    Cancer Applications

    Cyclosporins can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments.

Specifications

    Form

    Powder

    Appearance

    White powder

    Source

    Tolypocladium inflatum

    Assay

    ≥99.0% (HPLC, as is)

Technical Data

Spectral Data - Cyclosporin A, EvoPure®


HNMR Spectra


      

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Solvent: cdc13
Instrument: Mercury 300
Frequency: 300 MHz

 

FTIR Spectra

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Mass Spectra

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Polarity/Scan Type: Positive
Solvent: MeOH
Solution Concentration: 10 mg/mL
Instrument: Agilent
References

    References

    Stiller, C. R., MD, and R. A. Ulan, MD. "Cyclosporin A: A Powerful Immunosuppressant."Canadian Medical Association 126 (1981): 1041-046. www.ncbi.gov. Web. 27 Aug. 2012.

    Crabtree, G. R., J. Nourse, and L. Timmermann. "The Mechanism of Action of Cyclosporin A and FK506." Clinical Immunology and Immunotherapy (1996): 40-45.www.ncbi.gov. Web. 27 Aug. 2012.

    Wang, Paul C. et. al. "Isolation of 10 Cyclosporine Metabolites from Human Bile." Drug Metabolism and Disposition 17.3 (1989): 292-96. Nih.gov. Web. 28 Oct. 2013.

    Copeland, Kenneth R. "Immunosuppressive Activity of Cyclosporine Metabolites Compared and Characterized by Mass Spectrometry and Nuclear Magnetic Resonance."Clinical Chemistry 36.2 (1990): 225-29. Web. 28 Oct. 2013.

    Matsuda, Staoshi. "Mechanisms of Action of Cyclosporine." Immunopharmacology 47 (2000): 119-25. Elsevier. Web. 28 Oct. 2013.

    Laupacis, A., and P. A. Keown. "Cyclosporin A: A Powerful Immunosuppressant." Therapeutic Review 126 (1982): 1041-046. Nih.gov. Web. 6 Nov. 2013.

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