Cyclosporin A, EvoPure® is a neutral, cyclic oligopeptide with immunosuppressive activity. Cyclosporin A has the most potent immunosuppressive activity of all the metabolites (Cyclosporin B, C, D, E, and H). Cyclosporin A has been used to prevent organ transplant rejection. Cyclosporin A is soluble in ethanol (50 mM) and DMSO (100 mM).
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CAS Number
59865-13-3
Molecular Formula
C62H111N11O12
Molecular Weight
1202.6 g/mol
Mechanism of Action
After entering a T-cell, Cyclosporin A associates with the cytosolic protein cyclophilin which helps in protein folding. Cyclosporin A binds to cyclophilins and this complex binds another cytosolic protein phosphatase called Calcineurin (protein phosphatase 2B) that dephosphorylates a transcription factor (nuclear factor of activated T-cells, or NF-AT) needed for expression of interleukin 2 (IL-2.). It also blocks the pathway to nitric oxide synthesis via tumor necrosis factor (TNFa) and Interleukin 1a.
Storage Conditions
-20°C
Tariff Code
2933.79.8500