• Clarithromycin, USP packaged and labeled.

click on thumbnail to zoom
SKU: C033

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Clarithromycin is a macrolide antibiotic similar to erythromycin.  Clarithromycin is slightly soluble in aqueous solution (0.33 µg/mL).

    CAS Number

    81103-11-9

    Molecular Formula

    C38H69NO13

    Molecular Weight

    747.95

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to clarithromycin is commonly attributed to mutations in 50S rRNA preventing clarithromycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    Store in cool, dry conditions in well sealed containers.

    Tariff Code

    2941.50.0000

    Spectrum

    Clarithromycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria especially those which cause pharyngitis and otitis media.

Applications

    Microbiology Applications

    Clarithromycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenza 2 µg/mL - 32 µg/mL
    • Streptococcus pneumoniae 0.12 µg/mL – 64 µg/mL
    • For a complete list of clarithromycin MIC values, click here.

    Rose et al. used clarithromycin from TOKU-E in methacrylate-based copolymer films and studied their effects on biofilm formation: "Prevention of Biofilm Formation by Methacrylate-Based Copolymer Films Loaded With Rifampin, Clarithromycin, Doxycycline Aone or in Combination." 

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    ≤ 2.0%

    pH

    8.0-10.0

    Optical Rotation

    -94° to -102°

    Assay

    96.0-102.0% (on dried basis)

    Residue On Ignition

    ≤ 0.2%

    Heavy Metals

    ≤ 0.002%

    Impurities

    Any related compound: ≤1.0%
    Number of related compounds exceeding 0.4%:
    ≤ 4
    Total Impurities: ≤ 3.5%

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

Other Items In This Category