• Cefradine packaged and labeled.

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SKU: C057

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Description

Cefradine (also known as cephradine) is a first generation cephalosporin antibiotic which a has similar anti-bacterial spectrum of activity to cefalexin. Cefradine is freely soluble in aqueous solution at 21.3 mg/mL.

    CAS Number

    38821-53-3

    Molecular Formula

    C16H19N3O4S•H2O

    Molecular Weight

    349.40

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

Specifications

    Form

    Powder

    Appearance

    White to yellowish crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    ≤6.0%

    pH

    3.5-6.0

    Optical Rotation

    +80° to +90°

    Assay

    (On Dried Basis): 95.0-102.0%

    Sulfated Ash

    ≤0.2%

    Impurities

    7-ADCA: ≤1.0%
    Cyclohexa-1,4-dienylglycine: ≤1.00%
    Cefalexin: ≤5.0%
    N,N-Dimethylaniline: ≤20ppm
    Any Other Impurity: ≤1.0%

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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