• Cefprozil packaged and labeled.

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SKU: C017

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Description

Cefprozil is a semisynthetic, second-generation cephalosporin beta-lactam antibiotic with bactericidal activity.   Cefprozil is soluble in DMSO (10 mg/ml).  It is sparingly soluble in water (0.055 mg/ml). 

    CAS Number

    92665-29-7

    Molecular Formula

    C18H19N3O5S

    Molecular Weight

    389.43 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefprozil is a broad spectrum antibiotic targeting Gram-negative and Gram-positive bacteria such as those causing ear, nose, throat, and skin infections.

Applications

    Cancer Applications

    When cells become malignant, they often lose their primary cilium, a microtubule-based sensory organelle. Thus, the potential to restore the cilium is being investigated as a therapeutic approach to attenuate tumor growth in cancer research. Commonly used chemotherapeutic drugs like Cefprozil can restore ciliogenesis, and thus they are referred to as ciliogenic drugs. Using pancreatic cancer cell lines CFPAC-1 and PANC-1, researchers found a causative link between secreted ATP and cilia induction via an autocrine/paracrine loop involving extracellular ATP-purinergic receptor signaling pathway (Khan et al, 2017).

    Microbiology Applications

    Cefprozil is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Streptococcus pyogenes 0.015 µg/mL – 0.06 µg/mL
    • Haemophilus influenzae 4 µg/mL – 32 µg/mL
    • For a complete list of cefprozil MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White powder

    Source

    Semi-synthetic

References

    References

    Barriere SL (1992) Pharmacology and Pharmacokinetics of Cefprozil, Clin. Infect. Dis. 14 (2): S184–S188

    Khan, N et al (2017) Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway. Oncotarget 9 (3):3507-3518 PMID 29423062

    Naito T et al (1987) Synthesis and structure-activity relationships of a new oral cephalosporin, BMY-28100 and related compounds. J Antibiot (Tokyo) 40(7):991-1005. PMID 3624077

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