• Cefprozil packaged and labeled.

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SKU: C017

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Description

Cefprozil is a second generation cephalosporin antibiotic.  Cefprozil is freely soluble in aqueous solution (55 mg/mL).

    CAS Number

    92665-29-7

    Molecular Formula

    C18H19N3O5S

    Molecular Weight

    389.43 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefprozil is a broad spectrum antibiotic commonly targeting bacteria responsible for ear, nose, throat, and skin infections.

Applications

    Microbiology Applications

    Cefprozil is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Streptococcus pyogenes 0.015 µg/mL – 0.06 µg/mL
    • Haemophilus influenzae 4 µg/mL – 32 µg/mL
    • For a complete list of cefprozil MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White powder

    Source

    Semi-synthetic

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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