• Cefotetan packaged and labeled.

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SKU: C012

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Description

Cefotetan disodium is a cephamycin antibiotic grouped with the second generation cephalosporins. TOKU-E offers two forms of cefotetan: cefotetan (C012) and cefotetan disodium (C117). Ceftotetan is sparingly soluble in water (0.51 mg/mL) and cefotetan disodium is slightly more soluble at 1 mg/mL.

    CAS Number

    69712-56-7

    Molecular Formula

    C17H17N7O8S4

    Molecular Weight

    575.62

    Mechanism of Action

    Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactam antibiotics is commonly due to cells containing plasmid encoded β-lactamases, however, many cephamycins are unaffected by this mechanism.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Cefotetan is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria. Like many cephamycins, cefotetan is very effective against anaerobic bacteria such as Bacteroides and Clostridium species.

Applications

    Microbiology Applications

    Cefotetan is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against aerobic and anaerobic gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Bacteroides fragilis 2 µg/mL – 512 µg/mL
    • Clostridium difficile 8 µg/mL - 32 µg/mL
    • For additional cefotetan MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or light yellow powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    ≤2.5%

    Optical Rotation

    +112° to +124°

    Assay

    (On Dried Basis): 96.0-102.0%

    Residue On Ignition

    ≤0.1%

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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