• Aztreonam packaged and labeled.

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SKU: A017

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Description

Aztreonam is a β-lactam antibiotic known as a monobactam because of its unique structure which contains one rather than two rings fused together found in generic β-lactams such as ampicillin.  Because of its unique monocyclic structure, aztreonam is not typically inactivated by β-lactamases.

TOKU-E offers two forms of aztreonam: aztreonam (A017), and aztreonam solublized (A038).

    CAS Number

    78110-38-0

    Molecular Formula

    C13H17N5O8S2

    Molecular Weight

    435.43

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

    Spectrum

    Aztreonam targets primarily gram negative bacteria and shows little effect against gram positive and anaerobic bacteria.

Applications

    Microbiology Applications

    Aztreonam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against negative microbial isolates. Aztreonam has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa ≤0.12 µg/mL - >16 µg/mL
    • Proteus mirabilis ≤0.12 µg/mL - >16 µg/mL
    • For a complete list of aztreonam MIC values, click here.

    Plant Biology Applications

    Aztreonam is an economical broad spectrum antibiotic for plant tissue culture used especially for controlling Pseudomonas aeruginosa pathogens.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤ 2.0%

    Optical Rotation

    -26° to -32°

    Assay

    (On Dried Basis): 94.0-103.0%

    Residue On Ignition

    ≤ 0.1%

    Heavy Metals

    ≤ 0.001%

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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