• Aztreonam packaged and labeled.

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SKU: A017

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Description

Aztreonam is a β-lactam antibiotic originally isolated from Chromobacterium violaceum. It is categorized as a monobactam as it contains a single β-lactam ring instead of the fused β-lactam and thiazolidine rings found in generic β-lactams.  Due to its  unique structure, Aztreonam is not typically inactivated by β-lactamases. Aztreonam is used to combat Gram-negative bacteria in microbiology, cancer therapy, and plant tissue culture.  It is insoluble in water but is soluble in ethanol (20 mg/ml), DMSO (20 mg/ml) and DMF (30 mg/ml).

TOKU-E offers 2 forms of Aztreonam:

    CAS Number

    78110-38-0

    Molecular Formula

    C13H17N5O8S2

    Molecular Weight

    435.43

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

    Spectrum

    Aztreonam is effective against Gram-negative bacteria.

Applications

    Cancer Applications

    Aztreonam was effective as the single active antibiotic in the treatment of Gram-negative infections in neutropenic patients; however, it must be used in combination with another antibiotic to provide Gram-positive coverage.

    Microbiology Applications

    Aztreonam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against negative microbial isolates. Aztreonam has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa ≤0.12 µg/mL - >16 µg/mL
    • Proteus mirabilis ≤0.12 µg/mL - >16 µg/mL
    • For a complete list of aztreonam MIC values, click here.

    Plant Biology Applications

    Aztreonam is a broad-spectrum antibiotic commonly used in plant tissue culture to control bacterial contamination from Gram-negative species.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Synthetic

    Water Content (Karl Fischer)

    ≤ 2.0%

    Optical Rotation

    -26° to -32°

    Assay

    (On Dried Basis): 94.0-103.0%

    Residue On Ignition

    ≤ 0.1%

    Heavy Metals

    ≤ 0.001%

References

    References

    Jones PG et al (1986) Aztreonam therapy in neutropenic patients with cancer. Am. J. Med. 81(2):243-248. PMID 3526885

    Moreau-Marquis S, Coutemarsh B, Stanton BA (2015) Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate biofilms growing on cystic fibrosis airway epithelial cells. J. Antimicrob. Chemother 70(1):160-166. PMID 25213272

    Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am. J. Med. 1997; 103(1):51-59 PMID 9236486

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