• Apramycin sulfate packaged and labeled.

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SKU: A014

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Description

Apramycin sulfate is a freely soluble (25 mg/mL) aminoglycoside antibiotic which binds the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

    CAS Number

    65710-07-8

    Molecular Formula

    C21H41N5O11·H2SO4

    Molecular Weight

    637.66

    Mechanism of Action

    Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Gram negative bacteria such as E. coli and Salmonella spp. demonstrate susceptibility to apramycin sulfate.

Applications

    Microbiology Applications

    Apramycin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 1 µg/mL - >512 µg/mL
    • Klebsiella pneumoniae 2 µg/mL - >256 µg/mL
    • For a complete list of apramycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Yellowish powder

    Source

    Streptomyces tenebraius

    Assay

    (On Dried Basis): ≥550 units/mg

    Loss on Drying

    ≤10.0%

    Residue On Ignition

    ≤1.0%

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

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