Podophyllotoxin, a natural, non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species, was first isolated in 1880.
Serving as a model for antii-tumor properties, Podophyllotoxin has been used to inhibit the growth of various carcinoma cells. It has been used for testicular, breast, pancreatic, lung, stomach, and ovarian cancers. It is also used as an antiviral, and has been used against HPV and Molluscum contagisum.
