SKU: N062  / 
    CAS Number: 124858-35-1

    Nadifloxacin

    $102.74 - $308.23
    Nadifloxacin is a fluorinated fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, especially Propionibacterium acnes.  It also shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).  Nadifloxacin is capable of treating green nail syndrome caused by Pseudomonas aeruginosa.
    Mechanism of ActionNadifloxacin inhibits Topo II (DNA gyrase) in Gram-negative bacteria, and Topo IV in Gram-positive bacteria, which both function to relax positive supercoils prior to DNA replication, thus inhibiting bacterial multiplication.
    Spectrumbroad-spectrum activity against Gram-positive and Gram-negative bacteria.
    Molecular FormulaC19H21FN2O4
    SolubilityDMSO (20 mg/ml) @ 25°C) water (<1 mg/ml @ 25°C), ethanol (<1 mg/ml @ 25°C).
    ReferencesNarayanan V et al (2014) Efficacy and safety of nadifloxacin for bacterial skin infections: Results from clinical and post-marketing studies. Dermatol. Ther. 4:233-248 Müller S (2014) Green nail syndrome (Pseudomonas aeruginosa nail infection): Two cases successfully treated with topical Nadifloxacin, an acne medication. Case Rep. Dermatol. 6:180-184.