Miconazole Nitrate is the nitrate salt of Miconazole, an imidazole antimycotic compound patented in 1968 (Janssen Pharmaceutica). It targets the fungi that cause tinea (ringworm) and athlete’s foot. It inhibits ergosterol synthesis, and a variety of cytochrome P450 enzymes, and can be used for cytochrome P450 profiling. The compound can act as a chemopreventive agent in a mammary cancer cell model. Miconazole Nitrate is sparingly soluble in DMSO and DMF and very slightly soluble in ethanol.
We also offer:
- Miconazole (M041)
|Mechanism of Action||Miconazole Nitrate increases cell permeability by inhibiting enzymes involved in ergosterol synthesis, including a variety of cytochrome P450 enzymes including cytochrome P450-dependent 14-alpha-demethylase. The increase of permeability has a toxic effect on the fungi and leads to cell death. Miconazole can also act as an antagonist of the glucocorticoid receptor (GR) and can inhibit aromatase.|
|Spectrum||Miconazole Nitrate has activity against fungi including Candida, Trichophyton species. Trichophyton causes tinea (ringworm).|
|Microbiology Applications||Miconazole is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against fungal isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
For a representative list of Miconazole MIC values, click here.
Duret C et al (2006) Ketoconazole and Miconazole are antagonists of the human glucocorticoid receptor: Consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol. Pharmacol. 70(1):329–339 PMID 16608920
Ghannoum MA and Rice LB (1999) Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev. 12(4):501-517 PMID 10515900
Lubet et al (1997) Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, Miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model. Int. J. Cancer 72(1):95-101 PMID 9212229
Sreedhara KH, Sirsi M and Ramananda RGR (1974) Studies on the mechanism of action of Miconazole: Effect of Miconazole on respiration and cell permeability of Candida albicans. Antimicrob. Agents and Chemother. 5(4):420-425 PMID 15825399