Micafungin is a semi-synthetic cyclic lipopeptide antifungal belonging to the echinocandin class that was reported in 1999 from Fujisawa in Japan. Unlike other marketed semi-synthetic derivatives in this class, Micafungin is derived from FR901379, which contains a phenolic sulfate to enhance aqueous solubility, a serious limitation in the echinocandin class.
Micafungin is soluble in ethanol, methanol, DMF or DMSO. It has moderate water solubility.
|Mechanism of Action||Micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.|
Tawara S et al (2000) In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob. Agents Chemother. 44:57
Tomishima M et al (1999) FK463, a novel water-soluble echinocandin lipopeptide: Synthesis and antifungal activity. J. Antibiot. 52:674