SKU: M043  / 
    CAS Number: 73816-42-9

    Meclocycline Sulfosalicylate

    $79.00 - $277.50

    Meclocycline sulfosalicylate is a salt prepared from demeclocycline by taking advantage of the basic dimethylamino group, which protonates and readily forms a salt in solution with 2-hydroxy-3-carboxybenzenesulfonic acid. Like all tetracyclines, meclocycline shows broad-spectrum antibacterial and antiprotozoan activity. The unusual complex counter-ion is likely to add an antiseptic component to the use of the compound for skin infections.

    Meclocycline sulfosalicylate is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

    Mechanism of Action Like all tetracyclines, meclocycline acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
    Molecular Formula C29H27ClN2O14S
    References 6-Methylenetetracyclines. I A new class of tetracycline antibiotics. Blackwood R.K. et al. J. Am. Chem. Soc. 1961, 83, 2773.

    6-Methylenetetracyclines. III. Preparation and Properties. Blackwood R.K. et al. J. Am. Chem. Soc. 1963, 85, 3943.

    Meclocycline sulfosalicylate. Topical antibiotic agent for the treatment of acne vulgaris. Knutson D. D. Cutis. 1981, 27, 203.