Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents. Luzopeptin A is also a potent inhibitor of HIV-1 and HIV-2 reverse transcriptase.
Luzopeptin A is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
|Mechanism of Action
|Luzopeptin A acts by forming a stable DNA complex by bis-intercalation.
Inouye YJ et al (1987) Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. 40:100
Ohkuma H et al (1980) BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity. J. Antibiot. 33:1087