SKU: L007  / 
    CAS Number: 165800-03-3

    Linezolid

    $89.71 - $164.66

    Linezolid is an oxazolidinone antibiotic and is effective against Gram positive bacteria including certain strains of methicillin resistant Staphylococcus aureus (MRSA).

    Mechanism of ActionLinezolid inhibits protein synthesis by binding to the 50S ribosomal subunit (23S rRNA) which prevents formation of the 70S initiation complex thus inhibiting mRNA translation. It is also a monoamine oxidase inhibitor displaying nonselective, reversible binding.
    SpectrumEffective for Gram-positive bacteria including certain strains of MRSA.
    Eukaryotic Cell Culture ApplicationsLinezolid inhibits cytokine production from human peripheral blood monocytes in a dose-dependent manner. Linezolid was found to modify the acute phase inflammatory response. Linezolid inhibits cytokine production from human peripheral blood monocytes in a dose-dependent manner. (Garcia-Roca et al, 2006).
    Molecular FormulaC16H20FN3O4
    References

    Ament PW (2002)   Linezolid: Its role in the treatment of Gram-Positive, drug-resistant bacterial infections. Amer. Family Phys. 65(4):663-671

    Champney WS and Miller M (2002)  Linezolid is a specific inhibitor of 50S ribosomal subunit formation in Saphylococcus aureus cells. Curr. Microbiol. 44(5):350-356

    Garcia-Roca P, Mancilla-Ramirez J, Santos-Segura A, Fernandez-Aviles M, Calderon-Jaimes E (2006)  Linezolid diminishes inflammatory cytokine production from human peripheral blood mononuclear cells. 37(1):31-35

    Shinabarger DL (1997)  Mechanism of action of Oxazolidinones: Effects of Linezolid and Eperezolid on translation reactions.  Antimicrob. Agents Chemother. 41(10): 2132-2136