Lasalocid is a carboxylic polyether ionophore with potent antibacterial activity isolated from Streptomyces lasaliensis, first reported in 1951. It is a mixture of several related homologs(A, B, C, D and E) and Lasalocid has been found to have anticancer preoperties. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine. Lasalocid is used as an analytical standard to quantify the compound via methods including a) liquid chromatography with ultraviolet detection (LC-uv) for poultry feeds; b) liquid chromatography coupled to tandam mass spectrometry (LC-MS-MS) for animal liver and egg samples; and c) liquid chromatography-electrospray mass spectrometry (LC-EMS).
Lasalocid is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
We also offer:
- Lasalocid Sodium (L026)
|Mechanism of Action||
As an ionophore, the compound can increase the permeability of biological (or artificial) lipid membranes to specific ions.
Lasalocid induces autophagy via microtubule-associated protin 1 light chain 3 (LC-3)-II conversion. The autophagic properties were mediated via production of reactive oxygen species, confirmed by using a ROS inhibitor.
Berger J et al (1951) The isolation of three new crystalline antibiotics from Streptomyces. J. Am. Chem. Soc. 73:5295
Matabudul DK, Lumley ID and Points JS (2002) The determination of 5 anticoccidial drugs (nicrbazin, Lasalocid, monensin, salinomycin and narson) in animal livers and eggs by liquid chromatogrpahy linked with tandem mass spectrometry (LC-MS-MS). Analyst 127(6):760-768 PMID 12146908
Silva JM et al (2020) Multiple response optimization of a QuEChERS extraction and HPLC analysis of diclazuril, nicarbazin and Lasalocid in chicken liver. Food Chem. 311:126014