Isoapoptolidin, originally isolated from a Nocardiopsis sp., is a ring-expanded isomer of apoptolidin. In water, apoptolidin and isoapoptolidin equilibrate in a ratio of ~1.5:1 within hours. In a rapid F0F1-ATPase assay, isoapoptolidin was approximately half as potent as apoptolidin (IC50 17 μM vs. 0.7 μM ).
Isoapoptolidin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Isoapoptolidin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.