Antimicrobial peptides (AMP) have excellent bioactivity, especially against drug-resistant microbes, but their usefulness as clinical antimicrobials is marred by low bioavailability. AMPs are susceptible to proteolytic degradation. Peptoids are non-natural mimics of AMPs designed to resist proteolysis. In this paper by Czyzewski et al, the antibacterial activity and mechanism of action of peptoids are compared to classic antimicrobial peptides to look at peptoids as a promising new therapeutic class of antimicrobial agents.

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