SKU: H029  / 
    CAS Number: 55353-31-6

    Herbicidin A

    $266.16 - $931.59

    Herbicidin A is an antibiotic with selective herbidical activity against dicots.   It was originally isolated from Streptomyces saganonensis in a soil sample by Sankyo (Japan) in 1976.  It is the major analog of a family of adenosine-based  nucleosides containing a complex tricyclic saccharide.  Herbicidin A is soluble in ethanol, methanol, DMF and DMSO. 

    Mechanism of ActionThe mode of action and broader pharmacology of Herbicidin A has received little attention due to its restricted availability.
    Microbiology Applications

    Fermentation parameters for Herbicidin A production in submerged culture of Streptomyces scopuliridis M40 were investigated.  Bioproduction was successfully scaled up from a 5-L jar to a 500-L pilot vessel (Ha et al, 2017).

    Plant Biology Applications

    Bioherbicides include phytopathogenic microorganisms or microbial compounds useful for weed control.  Bioherbicides have several advantages: 1) high specificity, 2) absence of environmental residue; and 3) reduction of resistant weed populations (Hoagland RE et al, 2007).

    Herbicidin A is both a herbicide against weeds affecting dicot plants and an antibiotic against phytopathogens.   


    Arai M, Haneishi T, Kitahara N, Enokita R and Kawakubo K (1976)   Herbicidins A and B, two new antibiotics with herbicidal activity. I. Producing organism and biological activities.. J. Antibiot. (Tokyo) 29(9): 863-869

    Ha S et al (2017)  Optimization of herbicidin A production in submerged culture of Streptomyces scopuliridis M40. J. Micrrobiol. Biotechnol. 27(5):947-955 

    Haneishi T. et al. (1976)   Herbicidin A and B, two new antibiotics with herbicidal activity. II. Fermentation, isolation and physico-chemical characterization. Antibiot. (Tokyo) 29:870

    Hoagland RE, Boyette CD and Weaver MA (2007)  Bioherbicides: Research and risks. Toxin Rev. 26:313-342

    Lin G, Romo AJ, Liem PH, Chen Z and Liu H (2017)  Identification and interrogation of the herbicidin biosynthetic gene cluster: First insight into the biosynthesis of  arare undecose nucleoside antibiotic. J. Am. Chem. Soc. 139(46):16450-16453  PMID 29111702