Griseofulvin is an insoluble (8.64 µg/mL) fungistatic antifungal.
|Mechanism of Action||The mechanism of action of Griseofulvin is not well described, but is currently thought to bind to tubulin and interfere with mitosis. In addition, Griseofulvin is thought to inhibit synthesis of nucleic acids. It is able to induce apoptosis in human tumor cell lines.|
|Spectrum||Griseofulvin targets fungi, specifically those species causing ringworm (Microsporum, Epidermophyton, and Trichophyton).|
Panda D, Rathinasamy K, Santra MK, and Wilson L (2005) Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer. Proc Natl. Acad. Sci USA 102(28):9878-9883 PMID 15985553
Rice, LB and Mahmoud A. Ghannoum MA (1999) Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev. 501-517