SKU: G008  / 
    CAS Number: 126-07-8


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    Griseofulvin is an insoluble (8.64 µg/mL) fungistatic antifungal.

    Mechanism of ActionThe mechanism of action of Griseofulvin is not well described, but is currently thought to bind to tubulin and interfere with mitosis. In addition, Griseofulvin is thought to inhibit synthesis of nucleic acids. It is able to induce apoptosis in human tumor cell lines.
    SpectrumGriseofulvin targets fungi, specifically those species causing ringworm (Microsporum, Epidermophyton, and Trichophyton).

    Panda D, Rathinasamy K, Santra MK, and Wilson L (2005)  Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer. Proc Natl. Acad. Sci USA 102(28):9878-9883  PMID 15985553

    Rice, LB and  Mahmoud A. Ghannoum MA (1999)  Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev. 501-517