SKU: F001  / 
    CAS Number: 109581-93-3



    FK-506, also known as Tacrolimus, is a macrolide immunosuppressive drug commonly used post-transplant to reduce graft rejection. FK-506 is insoluble in aqueous solution.

    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    Mechanism of Action Tacrolimus forms complexes with other immune proteins which inhibit IL-2 cytokine production which ultimately suppresses T-cell proliferation and cytotoxicity.
    Eukaryotic Cell Culture Applications Tacrolimus can be used in mammalian cell culture to study the effects of T-cell mediated cytotoxicity.

    Thomson, A. W., and C. A. Bonham. "Mode of Action of Tacrolimus (FK506): Molecular and Cellular Mechanisms." Therapeutic Drug Monitoring 17.6 (1995): Pittsburgh Transplantation Institute, Dec. 1995. Web. 31 Aug. 2012.

    MIC Candida albicans| >10|| Cryptococcus neoformans| 12.5 - >25|| Malassezia dermatis| >32|| Malassezia furfur| 16 - ≥32|| Malassezia globosa| 16 - >32|| Malassezia japonica| ≥32|| Malassezia nana| ≥32|| Malassezia obtusa| 16 - >32|| Malassezia pachydermatis| ≥32|| Malassezia restricta| 16 - ≥32|| Malassezia slooffiae| 16 - >32|| Malassezia sympodialis| 16 - >32|| Malassezia yamatoensis| ≥32||