SKU: F016  / 
    CAS Number: 122547-49-3

    Faropenem sodium

    $251.48

    Faropenem sodium is a broad spectrum beta-lactam antibiotic belonging to the penem antibiotic class. Faropenem sodium is freely soluble in water (>20mg/mL).

    Mechanism of Actionβ-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like other antibiotics in the penem class, faropenem sodium is highly resistant to β-lactamases and some extended spectrum β-lactamases (ESBLs).
    SpectrumFaropenem sodium is a broad spectrum antibiotic and has shown to be very effective against anaerobic pathogens known to cause oral infections.
    Molecular FormulaC12H14NO5S • Na 
    Impurity ProfileFaropenem Isomer: ≤0.5%
    Maximum Single Impurity: ≤0.3%
    Heavy Metals: ≤20ppm
    ReferencesMilazzo, I. "Faropenem, a New Oral Penem: Antibacterial Activity against Selected Anaerobic and Fastidious Periodontal Isolates." Journal of Antimicrobial Chemotherapy 51.3 (2003): 721-25. Ncbi.gov. Web. 23 Jan. 2013.

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    MICBacteroides fragilis| 0.12 - 32|| Citrobacter freundii | 1.56 - 6.25|| Clostridium difficile| 1 - 8|| Clostridium perfringens| 0.25 - 1|| Enterobacter cloacae| 0.39 - 25|| Enterococcus faecalis| 0.5 - 8|| Enterococcus faecium| 2 - >256|| Escherichia coli| 0.125 - 3.13|| Haemophilus influenzae| 0.03 - 250|| Klebsiella pneumonia| 0.2 - 6.25|| Legionella pneumophila| ≤0.063|| Listeria sp| 0.06 - 0.5|| Moraxella catarrhalis| ≤0.006 - 1|| Morganella morganii | 0.78|| Neisseria meningitidis| 0.008|| Peptostreptococcus sp.| 0.008 - 1|| Proteus mirabilis| 3.13 - 12.5|| Proteus vulgaris | 0.78 - 6.25|| Providencia rettgeri | 0.39 - 3.13|| Pseudomonas aeruginosa| 0.5 - 512|| Salmonella sp| 0.25 - 4|| Serratia marcescens| 0.78 - >100|| Serratia sp.| 1 - 128|| Shigella sp.| 0.5 - 1|| Staphylococcus aureus | 0.05 - >128|| Staphylococcus epidermidis| ≥0.063 - >128|| Stenotrophomonas maltophilia| >100 - >128|| Streptococci| 0.03 - 0.13|| Streptococcus pneumonia| ≤0.006 - 4|| Streptococcus pyogenes| ≤0.006 - 0.025||