SKU: C099  / 
    CAS Number: 113981-44-5

    Cefozopran Hydrochloride


    Cefozopran Hydrochoride is a broad-spectrum, fourth-generation cephalosporin that interferes with bacterial peptidoglycan synthesis.  The product is freely soluble in DMSO and slightly soluble in water.

    Mechanism of Action Similar to β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
    Spectrum Cefozopran is a broad-spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa.
    Microbiology Applications Cefozopran has been shown to be useful against the multi drug resistant MRSA when used in combination with other antibiotics including vancomycin and teicoplanin.
    Molecular Formula C19H17N9O5S2•HCl
    Solubility Freely soluble in DMSO.  Slightly soluble in water.

    Georgopapadakou NH and Bertasso A (1992)  Mechanisms of action of Cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents Chemother. 37(3):559-565  PMID 8384817

    Iizawa Y et al (1993)  Therapeutic effect of Cefozopran (SCE-2787), a new parenteral cephalosporin, against experimental infections in mice.  Antimicrob. Agents Chemother. 37(1):100-105  PMID 8431004

    Toyokawa M et al (2003)  In vitro combined effects of Cefozopran/teicoplanin and Cefozopran/vancomycin on methicillin-resistant Staphylococcus aureus. J. Chemother.  15(1):31-36  PMID 12678411

    MIC Agrobacterium radiobacter| 1 - 16|| Alcaligenes faecalis| 0.5 - >64|| Bordetella bronchiseptica| 0.25 - >64|| Brevundimonas vesicularis| 1 - >64|| Burkholderia cepacia| 16 - >64|| Chryseobacterium indologenes| 0.5 - >64|| Chryseobacterium meningosepticum| 116 - >64|| Comamonas acidovorans| 4 - >64|| Ochrobactrum anthropi| 4 - >64|| Oligella ureolytica| 1 - >64|| Pseudomonas aeruginosa| 0.5 - 16|| Pseudomonas oryzihabitans| ≤0.06 - >64|| Pseudomonas stutzeri| ≤0.06 - >64|| Ralstonia pickettii | 0.25 - 4|| Sphingomonas spp.| 0.5 - 16|| Stenotrophomonas maltophilia| 32 - 256|| Weeksella virosa | 0.25 - 32||