Cefiderocol is a siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. It has in vitro activity against the non-fermenting Gram-negative bacteria causing urinary tract infections. It is a siderophore conjugate molecule, which means it's a single molecular structure with two distinct roles: a siderophore and a cephalosporin. Specifically, it combines a catechol-type siderophore and cephalosporin core with side chains similar to cefepime and ceftazidime. The cephalosporin moiety is the active antimicrobial component. Cefiderocol was developed by Shionogi & Co., Ltd. and was formerly called S-649266.
Cefiderocol is freely soluble in DMSO.