SKU: C003  / 
    CAS Number: 1405-37-4

    Capreomycin Sulfate


    Capreomycin Sulfate is the sulfate salt of Capreomycin, a broad-spectrum, cyclic peptide antiphlogistic antibiotic often grouped with the aminoglycosides.  The product is a mixture of 1A and 1B forms. It can be used to study bacterial ribosomes and protein synthesis.  It is bacteriostatic but can also be used to study multidrug-resistant tuberculosis. It was discovered from Streptomyces capreolus in 1960, with FDA filing by Eli Lilly in the US in 1971.

    Capremycin Sulfate is freely soluble in water.

    Mechanism of Action The mode of action of Capreomycin is not well defined but it is thought to inhibit protein synthesis by inhibiting normal ribosomal functions.
    Spectrum Capreomycin is used for Gram-positive, Gram-negative bacteria, and Mycobacteria including M. tuberculosis.  
    Molecular Formula 1A: C25H44N14O8 •H2SO4
    1B: C25H44N14O7 •H2SO4

    Akbergenov R et al (2011)  Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob. Agents Chemother. 55(10):4712-4717  PMID 21768509

    Liu XM and Xiu JP (2012)  Action and resistance mechanisms of Capreomycin: A functional genomic perspective.  Inst. Modern Biopharm. 43(8):788-792