Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines.
Apoptolidin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.
Apoptolidin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.