SKU: A019  / 
    CAS Number: 8063-24-9

    Acriflavine Hydrochloride

    $30.12 - $57.82

    Acriflavine HCl is a type of dye commonly used as a topical antiseptic for skin infections. Acriflavine is freely soluble in aqueous solution.

    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    Mechanism of ActionAcriflavine toxicity arises from its ability to bind to and intercalate DNA. DNA intercalation leads to numerous errors which have a lethal effect on targeted organisms.
    Microbiology ApplicationsAcriflavine has been used in RNA fluorescent labeling applications by RNA hydrolysis using HCl.
    Cancer ApplicationsAcriflavine has been shown to inhibit HIF-1, a heterodimeric transcription factor which responds to hypoxia and facilitates further cancer progress. Acriflavine prevents dimerization of HIF-1 to prevent its role in cancer growth.
    Molecular FormulaC13H11N3 and C14H14N3 •HCl
    References

    Kawai, Mako, and Et Al. "Mechanisms of Action of Acriflavine: Electron Microscopic Study of Cell Wall Changes Induced in Staphylococcus Aureus by Acriflavine."Microbiology and Immunology (2009): 481-86. Onlinelibrary.com. Web. 29 Aug. 2012.

    Levinson, J. W. "Fluorescent Labeling of Fragments of High Molecular Weight RNA." Energy Citations. N.p., n.d. Web. 18 Sept. 2012.

    Lee, K., and Et Al. "Acriflavine Inhibits HIF-1 Dimerization, Tumor Growth, and Vascularization." Proceedings of the National Academy of Sciences of the United States of America 106.42 (2009): 17910-7915. Pnas.org. 20 Oct. 2009. Web. 20 Sept. 2012.

    MICEscherichia coli| 2 - 128|| Klebsiella pneumonia| 128 - 512|| Staphylococcus aureus| 3.13 - 50||