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Description
Violacein is an intense violet pigment formed by the condensation of two tryptophan units, found in a number of bacteria, notably Chromobacterium violaceum. The regulation of pigment biosynthesis is the chromogenic basis for the use of C. violaceum CV26 for the detection of quorum sensing mediators. Violacein cell toxicity resembles TNF-α signal transduction.

Violacein is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    548-54-9

    Molecular Formula

    C20H13N3O3

    Molecular Weight

    343.3

    Mechanism of Action

    Violacein exhibits broad spectrum activity against bacteria, protozoans (including malaria), viruses and mammalian cell lines.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Violet blue solid

References

    References

    The chemistry of bacteria. Part II. Some degradation products of violacein. Beer R.J.S. et al. J. Chem Soc. 1949, 885.

    Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acyl homoserine lactones. McClean K.H. et al. Microbiol. 1997, 143, 3703.

    Molecular mechanism of violacein-mediated human leukemia cell death. Ferreira C.V. et al. Blood 2004, 104, 1459.

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