• Vancomycin packaged and labeled.

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SKU: V010

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Description

Vancomycin is a bactericidal glycopeptide antibiotic and has been used to treat infections caused by multi drug resistant bacteria including methicillin resistant Staphylococcus aureus (MRSA).

Vancomycin is freely soluble in water. Click here for more vancomycin products.

    CAS Number

    1404-90-6

    Molecular Formula

    C66H75Cl2N9O24

    Molecular Weight

    1449.25

    Mechanism of Action

    Vancomycin prevents peptidoglycan synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Vancomycin inhibits growth of many Gram positive bacteria including the antibiotic resistant superbug, MRSA (Methicillin resistant Staphylococcus aureus). Vancomcyin is effective for treating MRSA infections because it inhibits cell wall synthesis through a different mechanism than β-lactam antibiotics.

Specifications

    Form

    Powder

    Appearance

    White to off-white powder

    Source

    Streptomyces orientalis

    Impurity Profile

    Individual Impurity: Not more than 3.0%
    Related Substances: Not more than 7.0%
    Content of EDTA: Not more than 120 ppm

    Water Content (Karl Fisher)

    Not more than 20.0%

    Absorbance

    (465nm): Not more than 0.1

    Assay

    (As Is): Not less than 850 µg/mg
    (Dried Basis): Not less than 950 µg/mg

    Residue On Ignition

    Not more than 1.0%

    Heavy Metals

    Not more than 20 ppm

References

    References

    Courvalin, Patrice. "Vancomycin Resistance in Gram-Positive Cocci." Oxford Journals(2006): 25-34. Clinical Infectious Diseaes. Web. 21 Aug. 2012.

    Pollock, H.M., Holt J., and Murray C., Comparison of susceptibilities of anaerobic bacteria to cefemenoxime, ceftriaxone and other antimicrobial compounds, Antimicrob. Agents Chemother., Vol. 23, pp.780-783, 1983

    Silva J.A. and Fukai S., The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth, J. Appl. Hort., Vol. 3(1), pp. 3-12, 2001.

    Joshi, S., Ray, P., Manchanda, V., Bajaj, J., Chitnis, D. S., Gautam, V., &...Balaji, V. (2013). Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence & susceptibility pattern. Indian Journal Of Medical Research, 137(2), 363-369

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