• UCN-02 packaged and labeled in glass vial.

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SKU: U006

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Description
UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

UCN-02 is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    121569-61-7

    Molecular Formula

    C28H26N4O4

    Molecular Weight

    482.5

    Storage Conditions

    -20°C

Specifications

    Appearance

    White film

References

    References

    UCN-01-induced cell cycle arrest requires the transcriptional induction of p21waf1/cip1 by activation of mitogen-activated protein/extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway. Facchinetti M. M. et al. Cancer Res. 2004, 64, 3629. 

    UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century? Akinaga S. et al. Anticancer Drug Des. 2000, 15, 43. 

    UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. Takahashi I. et al. J. Antibiot. 1989, 42, 571.

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