SKU: T104

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Description
The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises the analogues, tunicamycins I to X. This composition is typical of other products less precisely described as tunicamycins A to D. The tunicamycins act by blocking the formation of N-glycoside linkages to proteins via inhibition of formation of dolichol monophosphate from N-acetylglucosamine-1-phosphate. Tunicamycins are broadly active against prokaryotes, eukaryotes and viruses.

Tunicamycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    11089-65-9

    Molecular Formula

    C38H62N4O16 (for IV)

    Molecular Weight

    830.4

    Mechanism of Action

    Tunicamycin blocks the synthesis of all N-linked glycoproteins (N-glycans) and causes cell cycle arrest in G1 phase.

References

    References

    Relationship of the structure and biological activity of the natural homologues of tunicamycin. Duskin D. & Mahoney W.C. J Biol Chem. 1982, 257, 3105.

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