The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises the analogues, tunicamycins I to X. This composition is typical of other products less precisely described as tunicamycins A to D. The tunicamycins act by blocking the formation of N-glycoside linkages to proteins via inhibition of formation of dolichol monophosphate from N-acetylglucosamine-1-phosphate. Tunicamycins are broadly active against prokaryotes, eukaryotes and viruses.
Tunicamycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Tunicamycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.