• Toxoflavin packaged and labeled in glass vial.

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SKU: T094

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Description
Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

Toxoflavin is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    84-82-2

    Molecular Formula

    C7H7N5O2

    Molecular Weight

    193.2

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow solid

References

    References

    Van Damme P.A. et al. Rec. Trav. Chim. 1960, 79, 255 (1960).

    On the biosynthesis of toxoflavin, an azapteridine antibiotic produced by Pseudomonas cocovenenans. Levenberg B. & Linton S.N. J. Biol. Chem. 1966, 241, 846.

    Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Wei W. et al. Int J. Cancer. 2010, 126, 2426.

    Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Lepourcelet M. et al. Cancer Cell. 2004, 5, 91.

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