• Tetrahydrolipstatin packaged and labeled in glass vial.

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SKU: T084

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Description
Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin is widely used for the treatment of obesity.

Tetrahydrolipstatin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    96829-58-2

    Molecular Formula

    C29H53NO5

    Molecular Weight

    495.7

    Mechanism of Action

    Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. Weibel E. et al. J. Antibiot. 1987, 40, 1081.

    Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin. Barbier P. et al. Helv. Chim. Acta 1987, 70, 196.

    The total synthesis of (−)-tetrahydrolipstatin. Bodkin J. et al. Aust. J. Chem 2003, 56, 795.

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