• Teicoplanin packaged and labeled.

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Description

Teicoplanin is a glycopeptide antibiotic composed of a mixture of related compounds used to treat infections caused by methicillin resistant Gram positive bacteria. Teicoplanin is sparingly soluble in water.

    CAS Number

    61036-62-2

    Molecular Formula

    A2-1 (CAS 91032-34-7) C88H95Cl2N9O33|1877.64|
    A2-2 (CAS 91032-26-7) C88H97Cl2N9O33|1879.65|
    A2-3 (CAS 91032-36-9) C88H97Cl2N9O33|1879.65|
    A2-4 (CAS 91032-37-0) C89H99Cl2N9O33|1893.68|
    A2-5 (CAS 91032-38-1) C89H99Cl2N9O33|1893.68|
    A3-1 (CAS 93616-27-4) C72H68Cl2N8O28|1564.25|
    A3-2 (CAS 91032-39-2) C66H58Cl2N8O23|1402.11|

    Molecular Weight

    Varies

    Mechanism of Action

    Teicoplanin prevents peptidoglycan synthesis and polymerization by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents cross-linking between amino acid residues in the peptidoglycan chain. This mechanism is nearly identical to vancomycin; however, teicoplanin is considered a safer drug due to its lower nephrotoxicity and ototoxicity.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.3000

    Spectrum

    Teicoplanin targets primarily gram positive bacteria especially those resistant to methicillin. These include the drug resistant superbug, MRSA (Methicillin resistant Staphylococcus aureus) and Enterococcus faecalis. Teicoplanin is effective for treating MRSA infections because it inhibits cell wall synthesis through a different mechanism than β-lactam antibiotics.

Applications

    Microbiology Applications

    Antimicrobial Susceptibility Testing (AST & MIC) teicoplanin is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Enterococcus faecalis 0.06 μg/mL - 0.25 μg/mL
    • Methicillin-resistant Staphylococcus aureus 0.125 μg/mL - >64 μg/mL

    For a complete list of teicoplanin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White to light yellow powder

    Elemental Analysis

    Composition:
    Teicoplanins A2: ≥80.0%
    Teicoplanins A3: ≤15.0%
    Other Impurities: ≤5.0%

    Impurity Profile

    Impurity A| 4-methylpent-3-en-2-one(mesityl oxide)|141-79-7|C6H10O|98.14|

    pH

    6.3-7.7

    Assay

    (On Dried Basis): ≥900 µg/mg

References

    References

    Murphy, S., and R. J. Pinney. "Teicoplanin or Vancomycin in the Treatment of Gram–positive Infections?" Journal of Clinical Pharmacy and Therapeutics 20.1 (2008): 5-11. Web. 15 Nov. 2012.

    Joshi, S., Ray, P., Manchanda, V., Bajaj, J., Chitnis, D. S., Gautam, V., &...Balaji, V. (2013). Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence & susceptibility pattern. Indian Journal Of Medical Research, 137(2), 363-369

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