• TAN 1364B packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: T066

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
TAN 1364B is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)

TAN 1364B is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    154639-24-4

    Molecular Formula

    C21H36O5

    Molecular Weight

    368.5

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Solid

References

    References

    Tetronic acid derivative, its production and use. Susumu S. et al. Japan Patent 5043568 1993.

    Asymmetric synthesis of a 3-acyltetronic acid derivative, RK-682, and formation of its calcium salt during silica gel column chromatography. Sodeoka M. et al. Chem. Pharm. Bull. 2001, 49, 206.

    3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity. Roggo B.E. J. Antibiot. 1994, 47, 136.

Other Items In This Category