• Retapamulin packaged and labeled in glass vial.

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SKU: R027

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Description
Retapamulin is a semi-synthetic pleuromutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. This enables formulation as a stable hydrochloride salt. Retapamulin is a broad spectrum antibiotic with no cross resistance to existing antibiotic classes, and is the first pleuromutilin approved for human use.

Retapamulin is soluble in ethanol, methanol, DMF and DMSO and has moderate water solubility.

    CAS Number

    224452-66-8

    Molecular Formula

    C30H47NO4S

    Molecular Weight

    517.8

    Mechanism of Action

    Retapamulin inhibits protein synthesis by binding to domain V of 23S rRNA.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Jones R. et al. Antimicrob. Agents Chemother. 2006, 50, 2583.

    Retapamulin. Daum R.S. et al. Nature Reviews Drug Discovery 2007, 6, 865.

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