• Milbemycin A3 oxime, EvoPure� packaged and labeled in glass vial.

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SKU: M058

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Description
Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections.

Milbemycin A3 oxime is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    114177-14-9

    Molecular Formula

    C31H43NO7

    Molecular Weight

    541.7

    Mechanism of Action

    Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Synthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae. Tsukamoto Y. et al. Agric. Biol. Chem. 1991, 55, 2615.

    Effects of milbemycin on adult Toxocara canis in dogs with experimentally induced infection. Bowman D.D. et al. Am. J. Vet. Res. 1988, 49, 1986.

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