SKU: M005

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Description

Miconazole nitrate is an imidazole antimycotic compound. Miconazole nitrate targets fungi that cause tinea (ringworm) and athleete's foot.

    CAS Number

    22832-87-7

    Molecular Formula

    C18H14Cl4N2O

    Mechanism of Action

    Miconazole nitrate increases cell permeability by inhibiting enzymes involved in ergosterol synthesis. The increase of permeability has a toxic effect on the fungi and leads to cell death.

    Storage Conditions

    2-8 °C

    Spectrum

    Miconazole targets fungi that cause tinea (ringworm) especially Trichophyton species.

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Melting Point

    178 - 183°C

    Loss on Drying

    Not more than 0.5%

References

    References

    Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

    Sreedhara, K. H. "Studies on the Mechanism of Action of Miconazole: Effect of Miconazole on Respiration and Cell Permeability of Candida Albicans." Antimicrobial Agents and Chemotherapy 5.4 (1974): 420-25. w ww.ncbi.gov. American Society for Microbiology. Web. 22 Aug. 2012.

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