• Micafungin packaged and labeled in glass vial.

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SKU: M044

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Description
Micafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class that was reported in 1999 from Fujisawa in Japan. Unlike other marketed semi-synthetic derivatives in this class, micafungin is not derived from echinocandin but rather from FR901379 which contains a phenolic sulfate to enhance aqueous solubility, a serious limitation in the class.

Micafungin is soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility.

    CAS Number

    235114-32-6

    Molecular Formula

    C56H71N9O23S

    Molecular Weight

    1270.3

    Mechanism of Action

    Micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi and is extensively referenced in the literature with over 700 citations.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    FK463, a novel water-soluble echinocandin lipopeptide: Synthesis and antifungal activity. Tomishima M. et al. J. Antibiot. 1999, 52, 674.

    In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Tawara S. et al. Antimicrob. Agents Chemother. 2000, 44, 57.

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