• Methacycline hydrochloride

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SKU: M003

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Description
Methacycline HCl is a member of the tetracycline antibiotics and is more active against Gram-negative and Gram-positive bacteria than tetracycline and demethylchlortetracycline.

    CAS Number

    3963-95-9

    Molecular Formula

    C22H22N2O• HCl

    Molecular Weight

    478.88

    Mechanism of Action

    Methacycline inhibits protein synthesis by preventing amino-acyl tRNA from binding to the “A” site in the bacterial ribosome.

    Storage Conditions

    ≤30°C

    Spectrum

    Metacycline has a broad spectrum of activity and is effective against several clinically significant pathogenic bacteria.

Applications

    Application

    Methacycline HCl can be used as a synthetic precursor of doxycycline hyclate.

Specifications

    Appearance

    Yellow crystalline powder

    Source

    Semi-synthetic

    Impurity Profile

    Oxytetracyline: Not more than 1.0%
    Doxycycline: Not more than 2.0%
    Other impurities: Not more than 0.5%
    Total impurities: Not more than 3.0%

    Water Content (Karl Fisher)

    Not more than 2.0%

    pH

    2.0 - 3.0

    Assay

    Not less than 877 Units/mg

References

    References

    Hubert, E. G., G. M. Kalmanson, J. Z. Montgomerie, and L. B. Guze. "Activity of Methacycline, Related Tetracyclines, and Other Antibiotics Against Various L-Forms and Their Parent Bacteria In Vitro." Antimicrobial Agents and Chemotherapy 2.4 (1972): 276-80.

    hopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance."Microbiology and Molecular Biology Reviews (2001): 232-60.Http://www.ncbi.nlm.nih.gov. Web. 21 Aug. 2012.

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