• Kijanimicin packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: K024

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitroaminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor active. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway.

Kijanimicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    78798-08-0

    Molecular Formula

    C67H100N2O24

    Molecular Weight

    1317.5

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Kijanimicin (Sch 25663), a novel antibiotic produced by Actinomadura kijaniata SCC1256. Waitz, J.A. et al. , J. Antibiot., 1981, 34, 1101.

    Antitumor activity of kijanimicin Bradner W. T. J. Antibiot. 1983, 36, 1078.

    Effect on tumor cells of blocking survival response to glucose deprivation. Park H.R. J. Natl. Cancer. Inst. 2004, 96, 1300.

    Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers. Nakajima H. Biochem Biophys Res Commun. 2007, 356, 260.

Other Items In This Category