• Illudin S packaged and labeled in glass vial.

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SKU: I019

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Description
Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumors.

Illudin S is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. 

    CAS Number

    1149-99-1

    Molecular Formula

    C15H20O4

    Molecular Weight

    264.3

    Storage Conditions

    -20°C

Specifications

    Appearance

    Light yellow solid

References

    References

    The structure of the basidiomycete metabolites, illudin S and illudin M. McMorris T.C. & Anchel M. J. Am. Chem. Soc. 1963, 85, 831.

    Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells: Unusually high sensitivity of ercc2 and ercc3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents. Kelner M.J. et al. Biochem. Pharmacol. 1994, 48, 403.

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