• Hygrolidin packaged and labeled in glass vial.

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SKU: H033

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Description
Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against Valsa ceratosperma, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumor cells, and inhibits the growth of solid tumor-derived cell lines such as DLD-1 human colon cancer cells with increased cells in G1 and S phases. Hygrolidin decreases cyclin-dependent kinase (cdk) 4, cyclin D and cyclin B, and increases cyclin E and p21 levels. Hygrolidin-induced p21 inhibits cyclin A-cdk2 complex more strongly than cyclin E-cdk2 complex. It also increases p21 mRNA in DLD-1 cells, but not in normal fibroblasts.

Hygrolidin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    83329-73-1

    Molecular Formula

    C38H58O11

    Molecular Weight

    690.9

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White solid

References

    References

    The structure of a new antibiotic, hygrolidin. Seto H. Tetrahedron Lett. 1982, 23, 2667.

    Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Kawada M. Biochem. Biophys. Res. Commun. 2002, 298, 178.

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