• Germacrone

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SKU: G061

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Description
Germacrone is extracted from the essential oil of Rhizoma Curcuma, and is known for its anticancer and antiviral activity. The activity of germacrone against cancer has been found by different researchers to inhibit angiogenesis, metastasis, cell proliferation, and in some cases induce apoptosis. Germacrone has showed protective properties against influenza infection, and to inhibit replication in other viruses.

    CAS Number

    6902-91-6

    Molecular Formula

    C15H22O

    Molecular Weight

    218.33

    Mechanism of Action

    Germacrone's anticancer activity is thought to induce apoptosis by inhibition of the JAK2/STAT3 signalling pathway.

    The antiviral activity of germacrone has been shown to inhibit the synthesis of viral DNA and proteins.

References

    References

    Liu, Y., Zheng, Q., Fang, B., Wang, W., Ma, F., Roshan, S., . . . He, G. (2013). Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway. Journal of Huazhong University of Science and Technology, 33(3), 339-345. doi:10.1007/s11596-013-1121-z

    Chen, Y., Dong, Y., Jiao, Y., Hou, L., Shi, Y., Gu, T., . . . Wang, C. (2015). In vitro antiviral activity of germacrone against porcine parvovirus. Arch Virol Archives of Virology, 160(6), 1415-1420. doi:10.1007/s00705-015-2393-3

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