SKU: G062

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Description

Gentamicin C2b sulfate, EvoPure® is one of several components in the Gentamicin C complex, along with Gentamixin C1 and C1a, and the complex comprises approximately 80% of Gentamicin and exhibits the highest antimicrobial activity. The higher antimicrobial activity of the group C Gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments.

    CAS Number

    66803-19-8

    Molecular Formula

    C20H41N5O· xH2SO4 (lot specific)

    Molecular Weight

    463.6 g/mol (Free base)

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1010

    Spectrum

    Gentamicin is a broad-spectrum antibiotic; however, it is mostly used to treat infections caused by Gram-negative bacteria. It is effective against several strains of Mycoplasma.

Applications

    Microbiology Applications

    Gentamicin EvoPure® compounds can be used to study effects of individual Gentamicin components on various bacterial strains.

Specifications

    Appearance

    White or off-white powder

    Source

    Micromonospora spp.

References

    References

    Davis, BD (1987) Mechanism of Bactericidal Action of Aminoglycosides. Microbiol. Rev. 51(3): 341-350 PMID 3312985

    Stypulkowska K, Blazewicz A, Fijalek Z, Sarna K.(2010) Determination of gentamicin sulphate composition and related substances in pharmaceutical preparations by LC with charged aerosol detection. Chromatograph. 72(11-12):1225-1229 PMID 21212825

    Vydrin, AF (2003) Component composition of gentamicin sulfate preparations. Pharma. Chem. J 37(8): 448-449

    Weinstein, MJ, Wagman GH, Oden EM and Marquez JA (1967) Biological activity of the antibiotic components of the gentamicin complex. J. Bacteriol. 94(3):789-790 PMID 4962848

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