• Galiellalactone packaged and labeled in glass vial.

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SKU: G051

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Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator.

Galiellalactone is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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    Mechanism of Action

    Recently Galiellalactone was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.

    Storage Conditions




    White Lyophilisate



    The high-intrinsic Diels-Alder reactivity of (-)-galiellalactone; generating four quaternary carbon centers under mild monditions, von Nussbaum F. et al. Eur. J. Org. Chem. 2004, 2783.

    Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities. Kopcke B. et al. J. Antibiot. 2002, 55, 36.

    Synthesis of (-)-galiellalactone. Johansson M. et al. J. Antibiot. 2002, 55, 663.

    Inhibition of interleukin-6 signaling by galiellalactone. Weidler M. et al. FEBS Lett. 2000, 484, 1.

    Screening of basidiomycetes and ascomycetes for plant growth regulating substances. R. Hautzel & H. Anke, Z. Naturforsch. 1990, 45c, 1094.

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