• Galiellalactone packaged and labeled in glass vial.

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SKU: G051

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Description
Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator.

Galiellalactone is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    133613-71-5

    Molecular Formula

    C11H14O3

    Molecular Weight

    194.2

    Mechanism of Action

    Recently Galiellalactone was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Lyophilisate

References

    References

    The high-intrinsic Diels-Alder reactivity of (-)-galiellalactone; generating four quaternary carbon centers under mild monditions, von Nussbaum F. et al. Eur. J. Org. Chem. 2004, 2783.

    Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities. Kopcke B. et al. J. Antibiot. 2002, 55, 36.

    Synthesis of (-)-galiellalactone. Johansson M. et al. J. Antibiot. 2002, 55, 663.

    Inhibition of interleukin-6 signaling by galiellalactone. Weidler M. et al. FEBS Lett. 2000, 484, 1.

    Screening of basidiomycetes and ascomycetes for plant growth regulating substances. R. Hautzel & H. Anke, Z. Naturforsch. 1990, 45c, 1094.

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