• Fumagillin packaged and labeled in glass vial.

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SKU: F029

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Description
Fumagillin is a polyene mycotoxin isolated from Aspergillus fumigatus in 1951 as a potent antiprotozoan for the treatment of amoebiasis. More recently, fumagillin has been shown to inhibit endothelial cell proliferation and angiogenesis.

Fumagillin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    23110-15-8

    Molecular Formula

    C26H34O7

    Molecular Weight

    458.6

    Mechanism of Action

    Fumagillin inhibits endothelial cell proliferation and angiogenesis by inhibiting methionine aminopeptidase-2 (MetAP-2).

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow powder

References

    References

    Fumagillin (H-3), a new antibiotic with amebicidal properties. McCowen M. C. et al. Science 1951, 23, 202.

    Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Griffith E. C. et al. PNAS 1998, 95, 15183.

    Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Lefkove B. et al. Expert Rev. Anti Infect. Ther. 2007, 5, 573.

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