• Filipin III, EvoPure� packaged and labeled in glass vial.

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SKU: F021

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Description
Filipin III is the major component of the filipin complex, a family of pentaene antifungal metabolites first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin III is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities.

Filipin III is soluble in ethanol, methanol, DMF or DMSO.

    CAS Number

    480-49-9

    Molecular Formula

    C35H58O11

    Molecular Weight

    654.8

    Mechanism of Action

    Filipin III acts by binding cell membrane sterols, disrupting membrane integrity. This sterol selectivity has led to the use of filipin III as a routine diagnostic probe for quantifying cholesterol in mammalian cells.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Pale yellow solid

References

    References

    Filipin, an antifungal antibiotic: Isolation and properties. Whitfield G.B. et al. J. Am. Chem. Soc. 1955, 77, 4799.

    Separation of polyene antifungal antibiotics by high speed liquid chromatography. Mechlinski W. & Schaffner C.P. J. Chromatogr. 1974, 99, 619.

    Inhibition of fungi by filipin and its antagonism by sterols. Gottlieb D. et al. Phytopathology 1960, 50, 594.

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