SKU: E057

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Description
Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound's polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.

Erythromycylamine is soluble in ethanol, methanol, DMF or DMSO. Good water solubility. 

    CAS Number

    26116-56-3

    Molecular Formula

    C37H70N2O12

    Molecular Weight

    735.0

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Erythromycin. VIII. Structure of dihydroerythronolide. Gerzon K. et al. J. Am. Chem. Soc. 1956, 78, 6396

    Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136: LY237216), a new macrolide antibiotic derived from erythromycin. Counter F.T. et al. Antimicrob. Agents Chemother. 1991, 35, 1116.

    Dirithromycin: Introduction and historical development. Kirst H.A. Drugs Today 1995, 31, 89.

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