• Eprinomectin B1a, EvoPure� packaged and labeled in glass vial.

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SKU: E051

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Description
Eprinomectin B1a is a semi-synthetic analogue of avermectin B1a prepared by oxidation of the 4''-hydroxy moiety and reductive amination followed by acetylation. Eprinomectin B1a is the major component (>90%) of the commercial product for endo- and exo-parasite control, eprinomectin. The avermectins and milbemycins are also potent insecticides and acaricides.

Eprinomectin B1a is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    133305-88-1

    Molecular Formula

    C50H75NO14

    Molecular Weight

    914.1

    Mechanism of Action

    Members of the avermectin/milbemycin class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    4-Keto- and 4-amino-4-deoxy avermectin compounds and substituted amino derivatives thereof. Mrozik H.H. et al. 1984 US Patent 4,427,663.

    Synthesis of 4"-epi-amino-4"-deoxyavermectins B1. Cvetovich R.J. et al. J. Org. Chem. 1994, 59, 7704.

    Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. Shoop W.L. et al. Int. J. Parasitol. 1996, 26, 1227.

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