• Epigallocatechin gallate

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SKU: E065

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Description
Epigallocatechin gallate, the catechin found in green tea (Camellia sinensis), has been reported to have an exhaustive list of promising bioactivity. Researchers have found it to have antiparasitic activity against Leishmania, antiviral activity against influenza A and hepatitis B viruses, and antifungal activity against Candida albicans. Broad-spectrum antibiotic activity against gram-negative and gram-positive bacteria including methicillin-resistant Staphylococcus aureus has also been demonstrated. Lastly, epigallocatechin gallate has exhibited anti-inflammatory effects and an ability to induce apoptosis selectively to transformed cells that promises anticancer activity.

Epigallocatechin gallate is soluble in water.

    CAS Number

    989-51-5Ā 

    Molecular Formula

    C22H18O11

    Molecular Weight

    458.4

References

    References

    Gordon, N. C., & Wareham, D. W. (2010). Antimicrobial activity of the green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia. International Journal of Antimicrobial Agents, 36(2), 129-131. doi:10.1016/j.ijantimicag.2010.03.025

    Hirasawa, M., & Takada, K. (2004). Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans. Journal of Antimicrobial Chemotherapy, 53(2), 225-229. doi:10.1093/jac/dkh046

    Inacio, J. D., Gervazoni, L., Canto-Cavalheiro, M. M., & Almeida-Amaral, E. E. (2014). The Effect of (-)-Epigallocatechin 3-O - Gallate In Vitro and In Vivo in Leishmania braziliensis: Involvement of Reactive Oxygen Species as a Mechanism of Action. PLoS Neglected Tropical Diseases, 8(8). doi:10.1371/journal.pntd.0003093

    Steinmann, J., Buer, J., Pietschmann, T., & Steinmann, E. (2013). Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea. British Journal of Pharmacology, 168(5), 1059-1073. doi:10.1111/bph.12009

    Wang, Y. C., & Bachrach, U. (2002). The specific anti-cancer activity of green tea (−)-epigallocatechin-3-gallate (EGCG). Amino Acids, 22(2), 131-143. doi:10.1007/s007260200002

    Zhong, Y., Chiou, Y., Pan, M., & Shahidi, F. (2012). Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages. Food Chemistry, 134(2), 742-748. doi:10.1016/j.foodchem.2012.02.172

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